منابع مشابه
Triiodothyronine potentiates angiogenesis-related factor expression through PI3K/AKT signaling pathway in human osteoarthritic osteoblasts
Objective(s): Previous study has indicated that triiodothyronine (T3) facilitated cartilage degeneration in osteoarthritis (OA). This study aimed to investigate the effects of T3 on angiogenesis-related factor expression in human osteoblasts of OA subchondral bone.Materials and Methods: The subchondral bone specimens were obtained from O...
متن کاملPI3K/AKT/mTOR Pathway in Angiogenesis
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated in the majority of human cancers. This pathway is known to play a key role in numerous cellular functions including proliferation, adhesion, migration, invasion, metabolism, and survival, but in the current review we focus on its role in angiogenesis. PI3K activation may occur via RAS mutation...
متن کاملTHE EFFECT OF AEROBIC TRAINING ON MUSCLE ANGIOGENESIS AND DOWNSTREAM FACTORS OF PI3KR2 PATHWAY IN CARDIAC TISSUE OF DIABETIC RATS
Background & Aims: Regarding the effect of diabetes on vascularization processes and since the beneficial effects of aerobic exercise on the cardiovascular system have been proven, therefore, the aim of this study was to determine the effect of aerobic exercise on muscle angiogenesis and downstream factors of the PI3KR2 pathway in cardiac tissue of diabetic rats. Materials & Methods: Twenty di...
متن کامل[Dll4/Notch signaling pathway and tumor angiogenesis.].
Dll4是定位于人染色体15q14、基因编码长度为685 个氨基酸的单链跨膜蛋白。它在进化过程中高度保守, 人和鼠Dll4基因编码的蛋白具有87%的同源序列。Dll4 的胞外段含有与Notch受体结合必需的8个表皮生长因子 (epidermal growth factor, EGF)样重复序列、4个潜在的 糖基化位点和1个由45个氨基酸组成的保守DSL(Delta, Serrate, Lag2)结构域。 Dll4通过与相邻细胞膜上的Notch1或Notch4受体相 互结合,使Notch受体经过一系列蛋白酶裂解。这个过 程主要包含2个蛋白酶,即肿瘤坏死因子α转换酶(tumor necrosis factor α-converzyme, TACE)和早老素(presenilin) 或称为γ-分泌酶(γ-secretase),受体裂解后释放出活化 形式的胞内区域(notch intrace...
متن کاملThe alternative complement pathway regulates pathological angiogenesis in the retina.
A defining feature in proliferative retinopathies is the formation of pathological neovessels. In these diseases, the balance between neovessel formation and regression determines blindness, making the modulation of neovessel growth highly desirable. The role of the immune system in these retinopathies is of increasing interest, but it is not completely understood. We investigated the role of t...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2011
ISSN: 1662-5099
DOI: 10.3389/fnmol.2011.00051